ToeJam & Earl in Panic on Funkotron is a platform video game, developed by Johnson Voorsanger Productions and published by Sega in 1993 for the Mega Drive. The game is the sequel to cult video game ToeJam & Earl, released in 1991. The game concerns two alien protagonists, ToeJam and Earl, both of whom have escaped from Earth, where they had crash landed. After returning to their home planet of Funkotron, the duo discover a number of antagonistic Earthlings have stowed away on the spacecraft and are wreaking havoc across the planet. The player must hunt down these Earthlings and imprison them in jars before sending them back to Earth. The game's platform format was a departure from the original ToeJam & Earl, a treasure hunt game with randomly generated levels, inspired by the game Rogue. Creators Greg Johnson and Mark Voorsanger originally began designing a game built on the concepts of the original, but changed to a more generic type of game due to a lack of support for their vision on the part of Sega. The game was critically well received, with reviewers praising the graphics, soundtrack, fluid action and two-player mode. It was also a commercial success, but fans of ToeJam & Earl were disappointed and confused by the radical change in direction. Since its release ToeJam & Earl in Panic on Funkotron has been criticized for being too sharp a departure from the first game, and some later reviewers felt that the developers had been more interested in the publisher's wishes than the fans. Johnson and Voorsanger have stated they regret moving away from their prototype sequel in the vein of ToeJam & Earl. Research has suggested that a significant minority of fans favor ToeJam & Earl in Panic on Funkotron as the best in the series. Together with its predecessor, the game comprises one of the Mega Drive's "key exclusive franchises", which eventually spawned a third installment in 2002, albeit a commercial failure with mixed reviews.

Tom and Jerry is an American animated series of short films created in 1940 by William Hanna and Joseph Barbera. It centers on a rivalry between its two main characters, Tom Cat and Jerry Mouse, and many recurring characters, based around slapstick comedy. Tom and Jerry has gained a worldwide audience and is one of the most popular and critically acclaimed cartoon series. In its original run, Hanna and Barbera produced 114 Tom and Jerry shorts for Metro-Goldwyn-Mayer from 1940 to 1957. During this time, they won seven Academy Awards for Animated Short Film, tying for first place with Walt Disney's Silly Symphonies with the most awards in the category. After the MGM cartoon studio closed in 1957, MGM revived the series with Gene Deitch directing an additional 13 Tom and Jerry shorts for Rembrandt Films from 1961 to 1962. Tom and Jerry then became the highest-grossing film series of all time, overtaking Looney Tunes. Chuck Jones then produced another 34 shorts with Sib-Tower 12 Productions between 1963 and 1967. Two more shorts were produced, The Mansion Cat in 2001 and The Karate Guard in 2005, for a total of 163 shorts. Various shorts have been released for home media since the 1990s. A number of spin-offs have been made, including the television series The Tom and Jerry Show (1975–77), The Tom and Jerry Comedy Show (1980–82), Tom & Jerry Kids (1990–94), Tom and Jerry Tales (2006–08), and The Tom and Jerry Show (2014). The first feature-length film based on the series, Tom and Jerry: The Movie, was released in 1992 before ten direct-to-video films were produced between 2002 and 2013. Numerous Tom and Jerry shorts have been subject to controversy, mainly over racial stereotypes which involves the portrayal of the recurring black character Mammy Two Shoes and characters appearing in blackface. Other controversial themes include cannibalism and the glamorization of smoking.

Toxic Crusaders is a side-scrolling, beat 'em up video game based on the American cartoon series Toxic Crusaders (1991). Troma Entertainment, in turn, based the cartoon series on their 1984 film The Toxic Avenger. Tose developed the game for the Nintendo Entertainment System. It was published by Bandai in 1992.

Trampoline Terror! (planned Japanese title: Explode Star) is a Sega Genesis video game that was released in 1990. It combines elements of strategy video games and overhead view action video games.