Alien3 is a 1992 video game published by Arena Entertainment, Acclaim Entertainment, LJN, Virgin Interactive and Tectoy for the Amiga, Commodore 64, and Sega Master System. It is based on the film of the same name. The game was also released for the Nintendo Entertainment System and Sega Genesis in 1993 and the Sega Game Gear in 1994.

Alien Soldier (エイリアンソルジャー?) is a side-scrolling run and gun video game developed by Treasure for the Sega Mega Drive. The game was released in Japan and Europe, but not physically in the US (one of the few to be released in this pattern), but it can be rather expensive due to its rarity in either region. The game was playable in America on the Sega Channel cable service and has been reissued for PlayStation 2 as part of the Sega Ages Treasure Box disc. The Sega Ages version, whose disc also includes Treasure's Gunstar Heroes and Dynamite Headdy, exceeds the Mega Drive's intrinsic sprite display limit, which eliminates slowdowns or missing graphics during busy scenes (e.g. boss fights with many explosions). Also, the player can select either the sprite-based pixelated graphics of the original game or a new mode that uses certain filters to produce a high-resolution look. The game was re-released again on the Nintendo Wii's Virtual Console download service in Japan on October 9, 2007, in Europe on November 2, 2007, and North America debut on November 5, 2007. The game is listed in Guinness World Records Gamers Edition 2010 under the category "Most boss battles in a run and gun game". The catchphrases seen on the title screen, "FOR MEGADRIVERS CUSTOM" and "VISUALSHOCK! SPEEDSHOCK! SOUNDSHOCK! NOW IS TIME TO THE 68000 HEART ON FIRE!", describe the game's technical prowess for the Mega Drive hardware, at the core of which is the Motorola 68000 CPU.

Alisia Dragoon (アリシア ドラグーン) is a 1992 platform game for the Sega Mega Drive/Genesis. It was developed by Game Arts, who also published the game in Japan. Aiding the software developer was animation studio Gainax, who was responsible for the game's art and story. The player controls Alisia, a young woman who is on a quest to avenge her father and save the world. She can fire lightning from her hands and summon four faithful beasts to aid her. The game was released in North America and Europe by Sega, who packaged the heroine as a rugged gladiator instead of the dainty-looking sorceress she originally was. Due to the lack of substantial market penetration by the Mega Drive of Japan and the lack of publicity for the game overseas, Alisia Dragoon did not make a big impact on the video game market, despite the critical acclaim it received. The game was one of the first in the industry to present a female character in a leading role.

Altered Beast (獣王記, Jūōki?, lit. "Beast King's Chronicle") is a 1988 beat 'em up arcade game developed and manufactured by Sega. The game is set in Ancient Greece, and follows a centurion who is resurrected by Zeus to rescue his daughter Athena, and to do so becomes able to turn into beasts such as the werewolf with the use of power-ups. After its initial arcade release, it was ported to several home video game consoles and home computers, including the Sega Mega Drive and Sega Genesis, for which it was a pack-in game. This ultimately led to the Sega Genesis being shipped with Sonic the Hedgehog instead. The primary designer was Makoto Uchida, also responsible for the creation of Golden Axe.

Amy Rose in Sonic the Hedgehog 2 (aka Amy in Sonic 2) is a character swap hack Sonic the Hedgehog 2 for the Sega Mega Drive/Genesis, with character Amy Rose as playable character in place of Sonic the Hedgehog. The game's sprites (modified from Sonic CD) use Amy's initial design prior to Sonic Adventure.The game was modified by Sonic Retro member E-122-Psi, with additional programming and coding by other members including MarkeyJester, MainMemory, FraGag, Selbi and Hayate.

Animaniacs is a video game that is based on the hit animated series of the same name. Unlike regular platform games, the player usually runs from the enemies rather than fighting them. Characters include Yakko, Wakko, and Dot, Pinky and the Brain, most of the supporting cast, as well as Ralph, the Warner Brothers studio guard. Animaniacs was made into two games which bore no relation to each other in terms of gameplay, despite both being made by Konami. One was for the Super Nintendo Entertainment System and the other was for the Sega Mega Drive/Genesis and Game Boy. The SNES and Mega Drive/Genesis version were released in 1994, and the Game Boy version in 1995.

Arcus Odyssey is an action role-playing game video game developed by Wolf Team. The game was released in 1991 for the Sega Mega Drive/Genesis, Sharp X68000 and Super Famicom. It featured an isometric perspective and cooperative gameplay. The game is a cross between fantasy and science-fiction themes,[citation needed] with hack and slash gameplay reminiscent of dungeon crawlers such as Dragon Slayer, The Tower of Druaga and Gauntlet. Arcus Odyssey is part of the Arcus franchise, which also included Arcus in 1988, Arcus II: Silent Symphony in 1989, and Arcus III in 1991. The music for the game was composed by Motoi Sakuraba, who also did the music for the Star Ocean series. An American version for the Super NES was planned, but it was cancelled following Sega's acquisition of Renovation Products (American publisher for Wolf Team and Telenet games). The Super NES version was, however, released in Japan, with the title Arcus Spirits.