Spider-Man and Venom: Maximum Carnage is a side-scrolling beat 'em up video game for the Super NES and Sega Mega Drive/Genesis, developed by Software Creations and published by LJN (a subsidiary of Acclaim) in 1994. The game, based on a sprawling comic book story arc of the same name, featured numerous heroes, including Spider-Man, Venom, and their allies from the Marvel Comics fictional universe like Captain America, Black Cat, Iron Fist, Cloak and Dagger, Deathlok, Morbius and Firestar, all teaming up to battle an onslaught of villains led by Carnage, including Shriek, Doppelganger, Demogoblin and Carrion.

The game featured a colored cartridge. Both the Sega Mega Drive/Genesis and Super Nintendo versions were red. They were later released in the normal cartridge colors (black for Genesis, gray for SNES).

The game was followed up by a sequel called Venom/Spider-Man: Separation Anxiety.

Universal Studios Orlando used Maximum Carnage as the theme for a haunted house at Halloween Horror Nights in 2002.