Dynamite Duke (ダイナマイトデューク?) is a 1989 action arcade game developed by Seibu Kaihatsu. It was later ported to the Sega Master System, Sega Mega Drive and Sharp X68000. Being a Cabal-based shooter, it can be considered a follow-up to Seibu's Empire City: 1931 and Dead Angle.

Dynamite Headdy (ダイナマイト・ヘッディー, Dainamaito Heddī?) is a platformer video game developed by Treasure. It was released in 1994 by Sega for the Sega Mega Drive/Genesis, Sega Game Gear and Sega Master System. A port for the Sega 32X was planned, but was cancelled due to the system's low popularity. It was later released for the Wii's Virtual Console in July 2007 and has also been included as a part of Gunstar Heroes: Treasure Box Collection for PlayStation 2 and Sonic's Ultimate Genesis Collection for Xbox 360 and PlayStation 3.

Earthworm Jim 2 is a run and gun platform video game starring an earthworm named Jim in a robotic suit who battles evil. It is a sequel to the original Earthworm Jim, and the second and final game in the Earthworm Jim series developed by original creators Doug TenNapel, David Perry, and Shiny Entertainment. It was released in late 1995 and early 1996 depending on region and video game console, initially being released for the Sega Genesis and Super Nintendo, before being ported to many other consoles.

Ecco: The Tides of Time is the second game in the Ecco the Dolphin series is the sequel to Ecco the Dolphin for the Sega Mega Drive, Game Gear, and Mega-CD, developed by Novotrade International and released in 1994. The Tides of Time continued the story of the first game and featured similar gameplay with a few new additions.

Elemental Master is a top down shoot 'em up video game developed by Tecno Soft for the Sega Mega Drive and released in 1990 in Japan, and in 1993 in North America by Renovation Products.

Eliminate Down (エリミネートダウン, Erimineto Daun?) is a horizontal scrolling shoot 'em up for the Sega Mega Drive developed by Aprinet and published by Soft Vision in 1993. The game gave players immediate access to three directional-based weapons that could all be powered up as they fought strange alien enemies through eight, enormous levels. The game was never released outside of Japan and South Korea.

Eternal Champions is a fighting game originally conceived by Scott Berfield, produced by Mike Latham for Sega of America, and developed by Sega Interactive Development Division in 1993. It was one of the only fighting games of its time developed from the ground up as a home console title, rather than being released in arcades first and later ported to home systems, as was the standard during that era. Sega released Eternal Champions for their Mega Drive/Genesis in 1993, hoping to capitalize on the fighting game mania that the game industry was in the midst of following the massive success of Street Fighter II (1991) and Mortal Kombat (1992). The game tried to set itself apart with unique features like a heavier emphasis on its story, characters pulled from different time periods, reflectable projectiles, force fields, fighters that carried weapons, a training mode where players had to defend themselves against robotic traps, a novel method of executing moves, and elaborate stage-specific finishing moves called "Overkills". Two years later, the sequel Eternal Champions: Challenge from the Dark Side (sometimes known as Eternal Champions CD or Eternal Champions 2) was released for the Mega-CD/Sega CD. There were also two spin-offs, action/adventure games set in the Eternal Champions universe and featuring some of its characters. Eternal Champions was added to the Wii's Virtual Console download service on December 3, 2007, where it became the first game to be rated 18 by PEGI in the service.