Tiny Toon Adventures: Buster's Hidden Treasure was the first Tiny Toon Adventures-based game released on the Mega Drive/Genesis. It was released in 1993 and developed and published by Konami.

ToeJam & Earl in Panic on Funkotron is a platform video game, developed by Johnson Voorsanger Productions and published by Sega in 1993 for the Mega Drive. The game is the sequel to cult video game ToeJam & Earl, released in 1991. The game concerns two alien protagonists, ToeJam and Earl, both of whom have escaped from Earth, where they had crash landed. After returning to their home planet of Funkotron, the duo discover a number of antagonistic Earthlings have stowed away on the spacecraft and are wreaking havoc across the planet. The player must hunt down these Earthlings and imprison them in jars before sending them back to Earth. The game's platform format was a departure from the original ToeJam & Earl, a treasure hunt game with randomly generated levels, inspired by the game Rogue. Creators Greg Johnson and Mark Voorsanger originally began designing a game built on the concepts of the original, but changed to a more generic type of game due to a lack of support for their vision on the part of Sega. The game was critically well received, with reviewers praising the graphics, soundtrack, fluid action and two-player mode. It was also a commercial success, but fans of ToeJam & Earl were disappointed and confused by the radical change in direction. Since its release ToeJam & Earl in Panic on Funkotron has been criticized for being too sharp a departure from the first game, and some later reviewers felt that the developers had been more interested in the publisher's wishes than the fans. Johnson and Voorsanger have stated they regret moving away from their prototype sequel in the vein of ToeJam & Earl. Research has suggested that a significant minority of fans favor ToeJam & Earl in Panic on Funkotron as the best in the series. Together with its predecessor, the game comprises one of the Mega Drive's "key exclusive franchises", which eventually spawned a third installment in 2002, albeit a commercial failure with mixed reviews.

Tony La Russa Baseball is a baseball computer and video game console sports game series (1991-1997), designed by Don Daglow, Michael Breen, Mark Buchignani, David Bunnett and Hudson Piehl and developed by Stormfront Studios. The game appeared on Commodore 64, PC, and Sega Genesis, and different versions were published by Electronic Arts, SSI and Stormfront Studios. The artificial intelligence for the computer manager was provided by Tony La Russa, then manager of the Oakland Athletics and later the St. Louis Cardinals. The game was one of the best-selling baseball franchises of the 1990s. The game was based on the baseball simulation methods Daglow evolved through the Baseball mainframe computer game (1971) (the first computer baseball game ever written), Intellivision World Series Baseball (1983) and Earl Weaver Baseball (1987). TLB refined many of the simulation elements of Earl Weaver Baseball, and introduced a few "firsts" of its own: User Interface and the Fly Ball Cursor -- Prior to Intellivision World Series Baseball in 1983 all hits in baseball games were grounders, since there was no way to display the ball in flight in 3D. After World Series Baseball, from 1983-1990 games had fly balls but used a ball-shaped shadow to trace the ball's path on the ground. This made catching fly balls difficult, since users couldn't tell how high the ball was if it was off the screen. In La Russa Daglow designed a circular Fly Ball Cursor that appeared where the ball was going to land, and grew or diminished in size based on the height of the ball. If the wind was blowing the cursor would move its location to reflect the changing course of the ball. The Fly Ball Cursor introduced real fly balls and pop-ups to computer baseball games, eliminating the last segment of the sport that had never been simulated accurately. Every graphic baseball game published since 1991 has used some variation on Daglow's Fly Ball Cursor for outfield play. Fantasy Draft -- La Russa was the first computer baseball game to allow users to conduct drafts and set up their own leagues, all with access to the game's comprehensive player statistics. Tony La Russa would draft on behalf of all non-human users in a league, and users could tune the AI draft strategy uniquely for each team. The draft features were enhanced in later versions. Head-to-Head Stats and Simulation Accuracy -- La Russa was the first baseball game to offer accurate stats for each individual pitcher against each individual hitter, data that actual managers use extensively in the dugout. Player stats and ratings were supplied by baseball sabermetrics pioneers John Thorn and Pete Palmer. Baseball stadiums -- Ballparks in the game were larger and more richly detailed than any prior game. Add-on disks allowed users to play in real Major League ballparks. AI -- In contrast to many sports celebrities who merely lent their names to games, Tony La Russa spent extensive sessions over a period of years working to make the game's artificial intelligence as accurate as possible. The team leveraged the lessons learned working with Earl Weaver to make the "baseball manager as game designer" feedback loop even more efficient. The first version of La Russa, Tony La Russa's Ultimate Baseball, was released almost exactly twenty years after the first playable version of Baseball went live at Pomona College in 1971.

Toy Story is a video game for the Sega Genesis, the Super Nintendo, Game Boy and Microsoft Windows. It is largely based on the movie of the same name. The game closely follows the plot of Toy Story, with a few minor differences. The game was followed by a sequel based on the second film.