Crack Down (クラックダウン?) is a run and gun arcade game originally released by Sega in 1989, and ported to the Sega Mega Drive/Genesis in 1990. It was also ported and released to a number of home computer platforms by U.S. Gold. The Mega Drive version of Crack Down was re-released on the Wii Virtual Console in Japan on August 7, 2007 and in PAL regions on September 7, 2007. It released also on Steam on June 1, 2010.

Crazy Driver is a simple homebrew driving game for Sega Genesis written mostly in C. Ports to Game Boy Advance and PC are also planned.

Crude Buster (クルードバスター?) (Kurūdo Basutā), released in the US as Two Crude, is a 1991 beat 'em up arcade game produced by Data East. The game was later ported to the Sega Genesis in 1992. Outside of Japan, the port was released under the name Two Crude Dudes. In the game, players control one of two mercenaries hired by the U.S. government to stop the terrorist organization "Big Valley." Their objective is to retake control of a ruined New York City from Big Valley after a nuclear explosion the group caused.

Crusader of Centy (also known as Soleil in Europe and Shin Sōseiki Ragnacënty (新創世紀ラグナセンティ, Shin Sōseiki Ragunasenti?) in Japan) is an action role-playing game game that was released on the Mega Drive/Genesis. The story centers on Corona, a boy who has just turned 14 years of age so must inherit his father's sword and fight the monsters that threaten the human race's very existence. Gameplay takes place in an overhead perspective and focuses on exploring, battling enemies with a sword, and solving puzzles. As the story progresses numerous animals join the hero and aid him, they are used in gameplay like weapons or tools, which often grant passage to previously inaccessible areas. The game's storyline is remarkable for questioning many of the traditional concepts of fantasy role-playing games, such as that monsters are inherently "evil".

Cutthroat Island is a 1995 action-adventure platform game that was developed by Software Creations and published by Acclaim Entertainment for various consoles. It is based on the film Cutthroat Island. When the game was first released, it featured a promotion by which players could find hidden treasure chests in the game and enter a contest to win real world prizes.

Daffy Duck in Hollywood is a 1938 Merrie Melodies animated short starring Daffy Duck (in his similar design from Daffy Duck & Egghead). This was the final Daffy Duck cartoon directed by Tex Avery.