Earth Defense (aka: The Earth Defend) is an unlicensed game for the Sega Mega Drive/Genesis; it was developed by AV Artisan and published by Realtec in both North America and Taiwan, without a license from Sega. The game cartridge and box shapes as well as quality in graphics and box art are identical to AV Artisan's previous titles Funny World & Balloon Boy and Whac-A-Critter, both published by Realtec. Earth Defense was also rare in that it was a simultaneous 2 player vertical scrolling shoot 'em up on the Genesis which primarily featured single player shoot 'em ups. The player takes on the role of a jet pilot assigned to liberate five world continents from a technologically advanced army.

Elemental Master is a top down shoot 'em up video game developed by Tecno Soft for the Sega Mega Drive and released in 1990 in Japan, and in 1993 in North America by Renovation Products.

ESPN SpeedWorld (formally Auto Racing '79-'86) is the name of a former television series broadcast on ESPN from 1979–2006. The program that was based primarily based around NASCAR, CART, IMSA, Formula One, NHRA, and IHRA. The theme music is a based on the piano interlude from "18th Avenue (Kansas City Nightmare)" by Cat Stevens.

Eternal Champions is a fighting game originally conceived by Scott Berfield, produced by Mike Latham for Sega of America, and developed by Sega Interactive Development Division in 1993. It was one of the only fighting games of its time developed from the ground up as a home console title, rather than being released in arcades first and later ported to home systems, as was the standard during that era. Sega released Eternal Champions for their Mega Drive/Genesis in 1993, hoping to capitalize on the fighting game mania that the game industry was in the midst of following the massive success of Street Fighter II (1991) and Mortal Kombat (1992). The game tried to set itself apart with unique features like a heavier emphasis on its story, characters pulled from different time periods, reflectable projectiles, force fields, fighters that carried weapons, a training mode where players had to defend themselves against robotic traps, a novel method of executing moves, and elaborate stage-specific finishing moves called "Overkills". Two years later, the sequel Eternal Champions: Challenge from the Dark Side (sometimes known as Eternal Champions CD or Eternal Champions 2) was released for the Mega-CD/Sega CD. There were also two spin-offs, action/adventure games set in the Eternal Champions universe and featuring some of its characters. Eternal Champions was added to the Wii's Virtual Console download service on December 3, 2007, where it became the first game to be rated 18 by PEGI in the service.