Arcade Classics is a Sega Mega Drive/Genesis game featuring three classic arcade games: Pong, Missile Command, and Centipede, plus a revised Sega version of each one. A version of the game was also released for the Sega Game Gear, with Ultrapong replacing Pong.

Sensible Soccer, often affectionately known as Sensi, is an association football video game series which was highly popular in the early 1990s and which still retains a cult following. Developed by Sensible Software and first released for Amiga and Atari ST computers in 1992 as well as for the PC, it featured a zoomed-out bird's-eye view (most games until then such as Kick Off and Matchday used a closer top-down or side view), editable national, club and custom teams and gameplay utilising a relatively simple and user-friendly control scheme. One of the defining gameplay elements was the aftertouch feature, which enabled effective but unrealistic swerves. The game topped charts such as Amiga Power's "All Time Top 100". The graphic style of the game was used in other Sensible Software games, such as Mega Lo Mania, Cannon Fodder and Sensible Golf.

Sesame Street: Counting Cafe is a Sega Genesis-only game based on the characters of Sesame Street, which is produced by the Children's Television Workshop (now known as Sesame Workshop). Players learn how to count numbers with Grover as he tries to count, climb, and jump while collecting food items for counting. Bert has a tendency to thrown an egg in the mass and alter the order.[15] The skills learned and developed in this game can be used for later childhood, adolescence, and eventually adulthood. North America was the only region in which the game was released; it uses the American English language.

Shadow Blasters (四天明王 Shiten Myouou or Shiten-Myooh) is a platform game developed by Sigma Enterprises for the Sega Genesis video game console in 1990. It was released in Japan and in North America in a localized form.

Shadow Dancer (シャドー・ダンサー?) is a side-scrolling action game produced by Sega originally released as an arcade game in 1989. It is the second arcade game in the Shinobi series, following the original Shinobi itself. The game was developed on the Sega System 18 motherboard hardware. Home versions were released for the Master System and various home computers. A remake was also developed for the Mega Drive/Genesis titled Shadow Dancer: The Secret of Shinobi.

Shadow of the Beast is a side-scrolling platform computer game produced by Reflections (Later known as Reflections Interactive) and published by Psygnosis in 1989. The original version was released for the Commodore Amiga but the game has been ported to many other systems. The original Amiga release cost £35, an unheard of price for a video game in that era, but it did include a T-shirt in the box bearing a print of the box's artwork. Psygnosis had published numerous side scrollers with high quality graphics prior to the release of Shadow of the Beast (most notably Obliterator). Shadow of the Beast, however, was considered revolutionary because its graphics, with many more colours on screen and up to twelve levels of parallax scrolling backdrops, were of a level rarely if ever seen before in action games. It was also notable for its atmospheric score composed by David Whittaker that used high-quality instrument samples. Shadow of the Beast will be remade on the PlayStation 4.

Shadowrun is an action role-playing game for the Sega Mega Drive/Genesis, adapted from the cyberpunk role-playing game Shadowrun by FASA, developed by BlueSky Software and released in 1994. The game is the second in a Shadowrun series of video game adaptations and has a more open ended style of gameplay than its 1993 precursor, Shadowrun by Beam Software.