Teenage Mutant Ninja Turtles: The Hyperstone Heist, released in Europe as Teenage Mutant Hero Turtles: The Hyperstone Heist and in Japan as Teenage Mutant Ninja Turtles: Return of the Shredder is a side-scrolling beat 'em up based on the Teenage Mutant Ninja Turtles (TMNT) franchise, and was also the first TMNT game released for the Sega Mega Drive/Genesis.

This is a video game first released in 1992 based on the original 1984 film of the same name. It was coded by Probe Software and released by Virgin Games on all the Sega video game consoles available at the time (Mega Drive/Genesis, Master System, Game Gear). In 1993, another game coded by Virgin Games USA was developed and released by Virgin for the Mega-CD/Sega CD. The Terminator by Probe Software is an action shooter game for the Mega Drive/Genesis programmed by David Perry and scored by Matt Furniss. The main character, Kyle Reese, traverses through levels that closely parallel the movie's environment. In all levels, the main character has a jump and has various weapons throughout the game. The first level takes place in the future, and the main character has hand grenades, timed bombs, and a machine gun as weapon choices. The later levels take place in modern settings, and the primary weapon is a shotgun only. The final level takes place inside the Cyberdyne factory, where you battle the Terminator alone. The objective of this level is to lead the Terminator into a compactor which destroys him. Conversions of this very same game were also developed by Probe for the Master System and Game Gear. The Mega-CD/Sega CD version, released by Virgin Games USA, was an entirely revamped game which had all-new levels, with development based on the David Perry engine, and was noted for its musical score by Tommy Tallarico, Bijan Shaheer, Joey Kuras, and TeknoMan. This music is generated in Q Sound. The objective is identical to the movie, which involves future soldier Kyle Reese going through the Time Displacement equipment located inside a Skynet base in the year 2029 AD, to go back in time to Los Angeles 1984 to protect Sarah Connor from the Terminator. It is considered to be the best game based on the original The Terminator. The name in text on the scrolling intro, "Hemdale's The Terminator" (only in the Mega Drive/Genesis version) refers to the independent Hemdale Film Corporation, who produced the original movie. Once the studio closed, Orion Pictures became the owner of most of the films Hemdale had once owned.

The Amazing Spider-Man vs. The Kingpin (also known as Spider-Man Vs. the Kingpin or simply Spider-Man) is a video game produced by Sega of America and developed by Technopop. It was released on the Sega Mega Drive/Genesis, Sega Master System, and Game Gear consoles; an updated version was also released for the Sega CD. All versions of the video game are side-scrolling platform games, whereby the player controls superhero Spider-Man to battle various supervillains (Doctor Octopus, Sandman, The Lizard, Hobgoblin, Vulture, Mysterio, Electro and Venom) to obtain the keys needed to disarm a nuclear bomb that the Kingpin has not only framed Spider-Man for stealing but plans to detonate within twenty-four hours. In the middle of the game, Spider-Man's wife Mary Jane Watson is also kidnapped by Venom.

The S Factor: Sonia and Silver is an in-progress multi-level hack created by Aquaslash of Sonic the Hedgehog on the Sega Mega Drive/Genesis. The game allows players to choose between two characters, Sonia, and Silver, and offers several moves attributed to those characters.

The Simpsons: Bart vs. the Space Mutants is the title of the first video game based on the animated television series The Simpsons. It was released in 1991 for the Nintendo Entertainment System, Sega Master System, Atari ST, Amiga, ZX Spectrum, Commodore 64, and Amstrad CPC, and in 1992 for Mega Drive/Genesis and Game Gear. It was published by Acclaim and Ocean Software, and developed by Imagineering and Arc Developments. In this platform game, the player controls Bart Simpson through five levels as he tries to ruin the aliens' plan to take over the world. Video game critics have given Bart vs. the Space Mutants mixed reviews, with criticism directed at the difficulty of the game, partly caused by restricted controls.

Virtual Bart is one of the many The Simpsons licensed games. It was released for the Super NES and Mega Drive/Genesis in 1994 by Acclaim. The official guide to the game (Virtual Bart: Official Game Secrets) was written by Steve Schwartz (Prima Publishing, 1995). A Virtual Boy port of this game was planned, however it was never released because of the failure of the console.

Theme Park is a construction and management simulation game designed by Bullfrog Productions and originally released in 1994, in which the player designs and operates an amusement park. Theme Hospital is Bullfrog's thematic successor to the game, while Chris Sawyer's RollerCoaster Tycoon series has evolved the concept to offer a far more realistic selection of rides.